Yale researchers have introduced countless medical and health advances over the last century, including the first success with antibiotics in the United States and the first use of chemotherapy to treat cancer. Yale scientists identified Lyme disease and discovered genes responsible for such disorders as high blood pressure, osteoporosis, dyslexia, and Tourette's syndrome. We did early work on the artificial heart and developed the first insulin pump to treat diabetes. Our investigators are also world-renowned for basic science research, including groundbreaking discoveries about how the cell and its components function at the molecular level.

As a partner with Yale School of Medicine and Yale New Haven Hospital, our surgeons and faculty are at the forefront of groundbreaking, life-saving research and are pioneers in developing more effective, safer methods and technologies in a range of surgical specialties and subspecialties.

Our groundbreaking research and discoveries continue to change surgical techniques and patient outcomes. A portion of this research includes:

Cardiac Surgery: Aortic surgery, transplantation, mechanical heart, and experimental cardiac transplantation research programs, as well as vascular biology and transplantation immunology, including the origin of coronary arteriosclerosis.

Endocrine Surgery: Laryngeal nerve assessment before and after minimally invasive parathyroidectomy for primary hyperparathyroidism, psychological and cognitive changes in primary hyperparathyroidism, and diagnosis, pathophysiology and molecular biology of pheochromocytoma.

Transplant & Immunology: Ways to decrease the gap between patients needing a transplant and organ availability, including increasing the donor pool with the use of living donations and split livers and reducing the number of patients with end-stage organ disease.

General Surgery, Trauma & Surgical Critical Care: Trauma resuscitation, pediatric trauma, surgical infections, mechanical ventilation, improvements in trauma care and quality of care, outcomes in intensive surgical care for veteran and geriatric patients, determining the sedative and analgesic sparing effect of music in the ICU, long-term outcomes in trauma and emergency surgery, ultrasound in trauma and critical care, and optimizing care in emergency surgery.

Vascular & Endovascular Surgery: Improved outcomes through new device development and studying the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular bypass surgery.

By participating in a clinical trial, our patients get access to the most advanced treatments that may be otherwise unavailable while helping to determine their benefits for future patients.

Visit to view available clinical trials or learn more about clinical research at Yale.