Our Approach

We offer a comprehensive and individualized approach to couples with RPL, which is traditionally defined as the loss of three or more consecutive pregnancies prior to 20 weeks of gestation. While the classic definition is limited to clinically identified pregnancies (those seen by ultrasound or under the microscope), biochemical pregnancies (those identified only by sensitive pregnancy tests) may also be included.  

Our providers encourage patients with recurrent first-trimester miscarriages or second- or third-trimester losses to seek counseling. We evaluate each patient individually in order to formulate a care plan specific to her needs. The initial evaluation includes a visit with a perinatologist and a reproductive immunologist, with other consultants available as needed. Even when no specific cause for the repeated losses can be identified, very close monitoring and support of a subsequent pregnancy is likely to result in a favorable outcome.

At the Yale Medicine Fertility Center, there are many types of assisted reproductive technologies offered for RPL couples. In cases where there is a shortage of eggs or the majority of eggs are damaged, leading to increased miscarriage risk, egg donation can be considered. Alternatively, if the sperm is problematic, donor sperm can be utilized. Finally, in cases where the uterus is affected by congenital or acquired factors that cannot be reversed, a gestational carrier can be used to carry the pregnancy that is generated from the egg and the sperm of the couple with RPL.

The goal of the RPL Program is to provide the most up-to-date and cutting-edge treatments for couples to overcome pregnancy losses. Our physicians continue to pursue research leading to potential new therapies for couples with RPL. At Yale Medicine, our goal is to help you achieve a healthy pregnancy.