Clinical Research

Yale Medicine's Department of Neurosurgery research covers a broad range of areas that reflects the diversity of state-of-the-art neuroscience research. Our research scientists are pioneers who continue to contribute to the fundamental understanding of neurological diseases and the development of new and effective treatments. We are committed to translating new research into clinical therapies.

 Our programs range from translational efforts based on work with patients to exploring central nervous system function at the cellular and molecular level. Please note that all patients receive the most current standard of care. Should any patient wish to participate in clinical trials, we have several available; this may be an option for select, eligible patients. Our success in clinical and basic science research complements our excellent in patient care. 

The efforts of the Yale Medicine Department of Neurosurgery have been recognized by the National Institutes of Health with numerous grants and awards, consistently making us one of the top three funded programs each year. Our areas of particular expertise include, but are not limited to: 

  • Serving as a leading center worldwide studying the genetics and genomics of brain tumors and aneurysms
  • Offering numerous clinical trials for brain tumor patients
  • Discovering targets of viruses that infect and break down cancer cells, understanding the role of immunotherapy, and the development and use of nanotechnology for the treatment of brain tumors
  • Proteomic (protein) profiles in temporal lobe epilepsy and improved surgical techniques for medically intractable epilepsy 
  • Understanding the mechanisms of aging in the olfactory system

  • Studying the regulation of ion transport across cell membranes in the central nervous system and how genetically encoded alterations can contribute to developmental disorders 
  • The use of deep brain stimulation (DBS) for psychiatric disorders 
  • The development of more powerful methods for MRI 
  • Deciphering a technique to prevent intraventricular hemorrhage, or bleeding into the fluid-filled areas of the brain, in preterm infants

Visit to view available clinical trials or learn more about clinical research at Yale.